After seeing dominant rivals Barcelona secure a La Liga and Spanish Cup Double there will be motivation for Cristiano Ronaldo to do his bit to prevent a moment of history when Real Madrid travel to the Nou Camp on Sunday.
Barca would be the first Spanish side to go through an entire league campaign unbeaten.
After Real, they face Villarreal, Levante and Real Sociedad in their remaining fixtures with only the former team still with something to play for in the form of Europa League qualification.
And although Champions League finalists Real can only finish as low as fourth in La Liga – enough to secure their place in the next season’s premier club competition should they be defeated by Liverpool on 26 May – there will be motivation to give their fans a lift in Catalonia, as well as attempting to overhaul city rivals Atletico to finish as runners-up.
Ronaldo, who has again been linked with a move back to Manchester United in the British press, has scored 11 times for Real at Barca the most recent of which came in his last outing at the stadium, in the Spanish Super Cup in August.
Barca though may be doubly determined to maintain their remarkable unbeaten run after confirmation that Real would not give the champions the traditional guard of honour ahead of the game – a tradition which has been common place in Spain since 1970, a decision criticised in the Spanish press.
Some of suggested it stems from Barca not giving Real a ‘pasillo’ at the Bernabeu in December after they had won the Club World Cup – a game in which the visitors won 3-0.
In what will be Andres Iniesta’s final El Classico, Real will be without Isco, Raphael Varane and Dani Carvajal, while Luca Modric, Toni Kroos and Marcelo could be rested.
Coach Zinedine Zidane said: “If anyone feels a problem they will not play. We have many players to come in for those missing, and that is the most important thing.”